TABLE 1

Alteration of voltage-dependent kinetics of the LCa

Activation
Inactivation
V1/2 (mV)k (mV)V1/2 (mV)k (mV)
Control−5.0 ± 0.9 (6)13.4 ± 0.9 (6)−25.0 ± 2.4 (6)11.5 ± 1.1 (6)
SNAP-251–206−3.2 ± 0.6 (5)11.2 ± 1.4 (5)−21.6 ± 3.1 (5)11.9 ± 0.3 (5)
BoNT/A−2.9 ± 0.4 (5)12.7 ± 1.5 (5)−26.4 ± 2.6 (5)11.6 ± 1.2 (5)
SNAP-251–197−15.1 ± 1.8 (6)*10.2 ± 1.9 (6)−24.7 ± 1.7 (5)11.2 ± 1.0 (5)
  • Data are means ± SE. The number of cells used is shown in parentheses. Definitions for V1/2 and k are given in the legend for Fig. 7.

  • *

    * P < 0.05 against control.