TABLE 2

Alteration of time-dependent kinetics of the LCa

Activation
Inactivation
τ (ms)τ1 (ms)τ2 (ms)
Control2.8 ± 0.2 (11)6,096.0 ± 505.2 (6)436.2 ± 27.4 (6)
SNAP-251–2062.9 ± 0.3 (11)4,127.6 ± 280.2 (6)*267.0 ± 36.9 (6)*
BoNT/A2.6 ± 0.4 (11)4,245.7 ± 273.9 (6)*245.6 ± 30.1 (6)*
SNAP-251–1972.0 ± 0.1 (11)*9,886.6 ± 1,028.2 (6)464.9 ± 47.9 (6)
  • Data are means ± SE. The number of cells used is given in parentheses.

  • *

    * P < 0.05

  • P < 0.01 vs. control.