TABLE 1

Insulin secretion in response to glucose from human islets cultured for 48 h with or without varying FFA mixture concentrations

FFA (mmol/l)Insulin secretion (μU/ml)
3.3 mmol/l glucose*16.7 mmol/l glucose*
0169 ± 21388 ± 76
1.0184 ± 23297 ± 88
2.0153 ± 23157 ± 51§
  • Data are means ± SD of 24 replicates from 8 pancreata.

  • *

    * P < 0.01 by ANOVA for the values in the column;

  • P < 0.01 vs. 3.3 mmol/l glucose by Student’s t test;

  • P < 0.05 vs. 3.3 mmol/l glucose and 0 and 1.0 mmol/l FFA, by Bonferroni test;

  • §

    § P < 0.05 vs. 16.7 mmol/l glucose and 0 and 1.0 mmol/l FFA, by Bonferroni test.