TABLE 2

Glucose oxidation and utilization (pmol−1 · islet−1 · 120 min−1) in control islets and islets cultured for 48 h with 2.0 mmol/l FFA mixture

Glucose oxidation
Glucose utilization
3.3 mmol/l glucose16.7 mmol/l glucose3.3 mmol/l glucose16.7 mmol/l glucose
Controls19.5 ± 8.741.9 ± 12.1*39.5 ± 12.7140.6 ± 45.8†
FFAs16.4 ± 10.025.9 ± 6.1‡27.5 ± 12.769.7 ± 24.8§

  • Data are means ± SD of four separate experiments.

  • *

    * P = 0.02 vs. controls, 3.3 mmol/l glucose;

  • †

    † P < 0.01 vs. controls, 3.3 mmol/l glucose;

  • ‡

    ‡ P = 0.05 vs. controls, 16.7 mmol/l glucose;

  • §

    § P = 0.02 vs. FFA, 3.3 mmol/l glucose and P < 0.05 vs. controls, 16.7 mmol/l glucose.