TABLE 1

Biological characteristics of the 7-day-old Wistar, untreated GK, GK/GLP-1, and GK/Ex rats

RatsBody wt (g)Plasma
Pancreas
Glucose (mmol/l)Insulin (pmol/l)Weight (mg)Insulin content
β-cell mass
(μg/pancreas)(μg/mg pancreas)(mg/pancreas)(μg/mg pancreas)
Wistar16.2 ± 0.3 (15)7.0 ± 0.2 (15)199.9 ± 10.4 (15)40.1 ± 1.5 (15)20.6 ± 0.5 (11)0.54 ± 0.02 (11)0.76 ± 0.06 (4)17.2 ± 1.1 (4)
GK untreated10.4 ± 0.2 (15)*6.6 ± 0.1 (15)114.4 ± 14.3 (15)*22.4 ± 0.8 (15)*4.9 ± 0.3 (15)*0.21 ± 0.01 (15)*0.20 ± 0.02 (4)*9.6 ± 0.7 (4)*
GK/GLP-18.8 ± 0.2 (15)*7.2 ± 0.1 (15)101.2 ± 5.1 (15)*21.9 ± 0.9 (15)*7.5 ± 0.5 (15)*§0.32 ± 0.04 (15)*0.38 ± 0.05 (4)14.6 ± 1.1 (4)
GK/Ex-49.2 ± 0.3 (15)*6.8 ± 0.2 (15)115 ± 11.3 (15)*22.9 ± 0.6 (15)*5.7 ± 0.3 (15)*0.26 ± 0.01 (15)*0.35 ± 0.04 (4)12.1 ± 1.1 (4)
  • Data are means ± SE (n of animals). Animals were in the nonfasted state.

  • *

    * P < 0.001,

  • P < 0.01,

  • P < 0.05 vs. Wistar rats;

  • §

    § P < 0.001,

  • P < 0.01,

  • P < 0.05 vs. untreated GK rats.