TABLE 2

Biological characteristics of Wistar, untreated GK, GK/GLP-1, and GK/Ex-4 female rats age 2 months

RatsBody wt (g)Plasma
Pancreas
Glucose (mmol/l)Insulin (pmol/l)Weight (mg)Insulin content
β-cell mass
(μg/pancreas)(μg/mg pancreas)(mg/pancreas)(μg/mg pancreas)
Wistar219.2 ± 4.5 (10)6.1 ± 0.2 (10)198 ± 28.4 (10)777.6 ± 29.8 (10)182.6 ± 8.7 (10)0.23 ± 0.01 (10)5.82 ± 0.11 (4)7.9 ± 0.65 (4)
GK untreated160.3 ± 4.2 (12)*9.2 ± 0.2 (12)*203.8 ± 26.7 (12)748.2 ± 17.8 (12)69.7 ± 3.8 (10)*0.09 ± 0.07 (10)*2.39 ± 0.03 (3)*3.38 ± 0.29 (3)*
GK/GLP-1165.1 ± 2.9 (15)*7.6 ± 0.1 (15)300.8 ± 36.6 (15)764.6 ± 18.6 (15)83.3 ± 7.2 (10)*0.11 ± 0.09 (10)4.13 ± 0.16 (3)*§5.29 ± 0.06 (3)*
GK/Ex-4156.5 ± 1.6 (15)*7.6 ± 0.2 (15)238.2 ± 23.1 (15)735.4 ± 32.0 (15)83.2 ± 5.9 (10)*0.12 ± 0.09 (10)3.71 ± 0.47 (3)4.41 ± 0.64 (3)
  • Data are means ± SE (n of animals). Animals were in the awake post-absorptive state.

  • *

    * P < 0.001,

  • P < 0.01,

  • P < 0.05 vs. Wistar rats;

  • §

    § P < 0.001,

  • P < 0.01,

  • P < 0.05 vs. untreated GK rats.