Biological characteristics of Wistar, untreated GK, GK/GLP-1, and GK/Ex-4 female rats age 2 months
| Rats | Body wt (g) | Plasma | Pancreas | |||||
|---|---|---|---|---|---|---|---|---|
| Glucose (mmol/l) | Insulin (pmol/l) | Weight (mg) | Insulin content | β-cell mass | ||||
| (μg/pancreas) | (μg/mg pancreas) | (mg/pancreas) | (μg/mg pancreas) | |||||
| Wistar | 219.2 ± 4.5 (10) | 6.1 ± 0.2 (10) | 198 ± 28.4 (10) | 777.6 ± 29.8 (10) | 182.6 ± 8.7 (10) | 0.23 ± 0.01 (10) | 5.82 ± 0.11 (4) | 7.9 ± 0.65 (4) |
| GK untreated | 160.3 ± 4.2 (12)* | 9.2 ± 0.2 (12)* | 203.8 ± 26.7 (12) | 748.2 ± 17.8 (12) | 69.7 ± 3.8 (10)* | 0.09 ± 0.07 (10)* | 2.39 ± 0.03 (3)* | 3.38 ± 0.29 (3)* |
| GK/GLP-1 | 165.1 ± 2.9 (15)* | 7.6 ± 0.1 (15)‡‖ | 300.8 ± 36.6 (15)¶ | 764.6 ± 18.6 (15) | 83.3 ± 7.2 (10)*¶ | 0.11 ± 0.09 (10)† | 4.13 ± 0.16 (3)*§ | 5.29 ± 0.06 (3)*‖ |
| GK/Ex-4 | 156.5 ± 1.6 (15)* | 7.6 ± 0.2 (15)‡‖ | 238.2 ± 23.1 (15) | 735.4 ± 32.0 (15) | 83.2 ± 5.9 (10)*¶ | 0.12 ± 0.09 (10)† | 3.71 ± 0.47 (3)†¶ | 4.41 ± 0.64 (3)† |
Data are means ± SE (n of animals). Animals were in the awake post-absorptive state.
* P < 0.001,
† P < 0.01,
‡ P < 0.05 vs. Wistar rats;
§ P < 0.001,
‖ P < 0.01,
¶ P < 0.05 vs. untreated GK rats.