TABLE 3

Insulin secretory rates from perfused pancreas of Wistar, GK, GK/GLP-1, and GK/Ex-4 in response to 16.7 mmol/l glucose and 19 mmol/l arginine

SecretagoguesΔI (pmol/l insulin · min−1)
WistarGKGK/GLP-1GK/Ex-4
Glucose (16.7 mmol/l)1360 ± 195 (6)109 ± 24 (6)*180 ± 21 (6)*115 ± 9 (7)*
Arginine (19 mmol/l)3165 ± 480 (6)3330 ± 754 (6)2280 ± 343 (6)5220 ± 780 (7)
  • Data are means ± SE of six to seven perfusions (number of perfusions indicated in parentheses). Total insulin response to glucose or arginine stimulation was obtained by planimetry of the individual perfusion profiles and expressed as the difference in hormonal secretion rate relative to the mean hormonal output recorded during the prestimulation period.

  • *

    * P < 0.001 vs. Wistar rats;

  • P < 0.05 vs. untreated GK rats.