TABLE 1

Plasma FFA and TG levels in ZDF rats

Plasma FFA (mEq/l)
Plasma TG (ng/ml)
Day −1Day 19Day −1Day 19
Lean FA/?
 No treatment0.64 ± 0.040.65 ± 0.0461.6 ± 4.194.5 ± 4.6
Obese fa/fa
 Vehicle1.81 ± 0.17*3.10 ± 0.1*348.6 ± 16.7*1254.5 ± 45*
 FE 999011 once a day1.76 ± 0.1*2.40 ± 0.4*342.2 ± 13.6*993.6 ± 130.9*
 FE 999011 twice a day1.52 ± 0.16*1.84 ± 0.18*327.3 ± 39.7*672.4 ± 69*
  • *

    * P < 0.05 vs. lean;

  • P < 0.05 vs. obese vehicle;

  • P < 0.05 vs. obese FE 999011 once daily.