TABLE 1

Venular diameter and venular shear rates in rat mesenteric venules stimulated with 25 mmol/l d-glucose for 12 h and superfused with K-H alone or K-H buffer containing 30 nmol bisindolylmaleamides

GroupnVenular diameter (μm)Venular shear rate
Baseline (0 min)60 min120 min
0.9% NaCl + Krebs-Heseleit626.6 ± 1.9674 ± 48*767 ± 82*798 ± 31*
0.9% NaCl + 30 nmol/l bisindolylmaleamide-I625.7 ± 1.1865 ± 113*825 ± 75*795 ± 96*
25 mmol/l d-glucose632.1 ± 0.9499 ± 32484 ± 38447 ± 23
25 mmol/l d-glucose + 30 nmol/l bisindolylmaleamide-V532.0 ± 0.9537 ± 51494 ± 33495 ± 56
25 mmol/l d-glucose + 30 nmol/l bisindolylmaleamide-I630.0 ± 1.8533 ± 57543 ± 105592 ± 112
  • Data are means ± SE.

  • *

    * P < 0.01 vs glucose-injected groups.