∼1 SD change | Univariate hazard ratio (95% CI) | P | Multivariate hazard ratio (95% CI) | P | |
---|---|---|---|---|---|
Age | 5 years | 1.03 (0.88–1.21) | 0.68 | 1.00 (0.84–1.19) | 1.00 |
BMI | 3 kg/m^{2} | 1.64 (1.43–1.88) | <0.0001 | 1.28 (1.10–1.49) | 0.0012 |
Ln(WCC) | 0.25 ln(10^{9} cells/l) | 1.41 (1.20–1.65) | <0.0001 | 1.14 (0.94–1.38) | 0.19 |
Systolic blood pressure | 20 mmHg | 1.22 (1.00–1.48) | 0.05 | 1.02 (0.83–1.25) | 0.86 |
Ln(triglyceride) | 0.5 ln(mmol/l) | 2.25 (1.81–2.79) | <0.0001 | 1.42 (1.03–1.96) | 0.031 |
Total cholesterol | 0.5 mmol/l | 1.26 (1.10–1.45) | 0.0008 | 1.04 (0.87–1.24) | 0.69 |
HDL cholesterol | 0.25 mmol/l | 0.60 (0.49–0.75) | <0.0001 | 0.84 (0.64–1.09) | 0.18 |
Alcohol | 10 units/week | 1.02 (0.89–1.16) | 0.83 | 0.95 (0.82–1.10) | 0.48 |
Smoking | Y/N | 1.13 (0.80–1.60) | 0.5 | 0.95 (0.66–1.49) | 0.97 |
Pravastatin therapy | 0.70 (0.49–0.99) | 0.045 | 0.72 (0.50–1.03) | 0.070 | |
Ln(CRP) | 1 ln(mg/l) | 1.55 (1.32–1.82) | <0.0001 | 1.30 (1.07–1.58) | 0.0075 |
Glucose | mmol/l | ||||
Quintile I: <4.3 | Referent level | Referent level | |||
Quintile II: >4.3 to 4.5 | 0.98 (0.35–2.75) | 0.90 (0.32–2.54) | |||
Quintile III: >4.5 to 4.7 | 0.42 (0.11–1.85) | <0.0001* | 0.38 (0.10–1.42) | <0.0001* | |
Quintile IV: >4.7 to 5.0 | 1.53 (0.85–3.58) | 1.31 (0.56–3.08) | |||
Quintile V: >5.0 | 11.9 (6.0–23.7) | 8.78 (4.37–17.6) |
Univariate and multivariate hazard ratios with P values and approximate 95% CIs for baseline predictors of development of diabetes. The given hazard ratio for continuous covariates is for an approximate 1 SD change; for example, for log(triglyceride) the hazard ratio is for a 0.5 unit change in the logarithm of triglyceride (with triglyceride measured in millimoles per liter). For categorical variates, the hazard ratio is with or without the stated attribute, e.g., smoker or nonsmoker. Ln, natural logarithm.
* P for the χ^{2} test on four degrees of freedom for the equality of the five quintiles.