TABLE 2

Genotype and allele distribution of VEGF gene polymorphisms in type 2 diabetic patients with and without retinopathy

GenotypeRetinopathy (−) n = 118Retinopathy (+)
AlleleRetinopathy (−) n = 236Retinopathy (+)
All (P) n = 150Non-PDR (P) n = 80PDR (P) n = 70All (P) n = 300Non-PDR (P) n = 160PDR (P) n = 140
T(−1498)C-G(−1190)A
TT-GG44.152.7 (NS)52.5 (NS)52.9 (NS)T-G68.272.0 (NS)73.1 (NS)70.7 (NS)
TC-GA48.338.741.335.7C-A31.828.026.929.3
CC-AA7.68.76.311.4
G(−1154)A
GG74.676.0 (NS)80.0 (NS)71.4 (NS)G86.986.7 (NS)89.4 (NS)83.6 (NS)
GA24.621.318.824.3A13.113.310.616.4
AA0.82.71.34.3
C(−634)G
CC10.320.7* (0.011)18.8 (0.0026)22.9 (NS)C35.247.7 (0.0037)50.6 (0.0026)44.3 (NS)
CG50.054.063.842.9 (0.061)G64.852.349.455.7 (0.081)
GG39.825.317.5§34.3
C(−7)T
CC66.170.0 (NS)68.8 (NS)71.4 (NS)C80.984.0 (NS)82.5 (NS)85.7 (NS)
CT29.728.027.528.6T19.116.017.514.3
TT4.22.03.80.0
C936T
CC72.062.0 (NS)61.3 (NS)62.9 (NS)C85.277.7 (0.035)78.1 (NS)77.1 (NS)
CT26.331.333.828.6 (0.064)T14.822.321.9 (0.081)22.9 (0.052)
TT1.76.75.08.6
G1612A
GG78.077.3 (NS)73.8 (NS)81.4 (NS)G87.387.3 (NS)86.3 (NS)88.6 (NS)
GA18.620.025.014.3A12.712.713.811.4
AA3.42.71.34.3
  • Data are %. T(−1498)C and G(−1190)A polymorphisms are in complete linkage disequilibrium in patients and are shown together. P values versus patients without retinopathy are shown (P values between 0.05 and 0.1 are shown in parentheses).

  • *

    * P = 0.029,

  • P = 0.021,

  • P = 0.012,

  • §

    § P = 0.0009 vs. patients without retinopathy.