TABLE 1

Blood cell counts, coagulation, and complement parameters before and after 60 min of human islet perfusion with fresh ABO-compatible blood

0 min60 min
No islets*No islets*Islets
No Melagatran10 μmol/l Melagatran
n10101010
Platelets (×109/l)240 ± 11160 ± 7.62.4 ± 1.1170 ± 8.2
Lymphocytes (×109/l)2.2 ± 0.12.0 ± 0.11.7 ± 0.12.0 ± 0.1
Monocytes (×109/l)0.4 ± 0.00.5 ± 0.10.1 ± 0.00.6 ± 0.1
Granulocytes (×109/l)4.0 ± 0.33.8 ± 0.31.0 ± 0.13.7 ± 0.3
TAT (μg/l)9.4 ± 2.2470 ± 8716000 ± 2900890 ± 160
Prothrombin F1+2 (nmol/l)1.5 ± 0.225 ± 5.11000 ± 180110 ± 28
FXIa-AT (μmol/l)0.02 ± 0.00.4 ± 0.114 ± 2.60.9 ± 0.6
β-TG (IU/ml)520 ± 1301300 ± 1804000 ± 4501300 ± 200
C3a (ng/ml)120 ± 15530 ± 62950 ± 140510 ± 50
sC5b-9 (AU/ml)24 ± 3.4130 ± 16180 ± 31140 ± 17.0
Insulin (mU/l)12 ± 4.310 ± 4.0460 ± 1401500 ± 350
  • Data are means ± sem.

  • *

    * Control containing blood and medium, but no islets.

  • Significant difference when compared with the control loop after 60 min of perfusion.

  • Significant difference when compared with the islet loops with no Melagatran.