TABLE 3

Glucose turnover and indirect calorimetry data during a hyperinsulinemic-euglycemic clamp

Basal
Clamp
Pretreatment10 weeksPretreatment10 weeks
Glucose infusion rate (mg · kg−1 · min−1)4.29 ± 0.825.05 ± 0.87*
Whole-body glucose disposal (mg · kg−1 · min−1)2.56 ± 0.162.62 ± 0.163.91 ± 0.694.73 ± 0.70*
Glucose clearance rate (ml · kg−1 · min−1)1.72 ± 0.132.10 ± 0.094.58 ± 0.895.29 ± 0.87*
Nonoxidative glucose disposal (mg · kg−1 · min−1)1.12 ± 0.241.16 ± 0.201.50 ± 0.502.48 ± 0.45*
Endogenous glucose production (mg · kg−1 · min−1)2.54 ± 0.202.66 ± 0.13−0.49 ± 0.07−0.20 ± 0.10
Glucose oxidation (mg · kg−1 · min−1)1.43 ± 0.161.46 ± 0.102.40 ± 0.222.25 ± 0.35
Fat oxidation (mg · kg−1 · min−1)0.86 ± 0.080.84 ± 0.060.57 ± 0.060.56 ± 0.08
Energy expenditure (kcal · kg−1 · 24 h−1)22.01 ± 0.4821.48 ± 0.3621.36 ± 0.5921.49 ± 0.68
Glucose (mmol/l)8.3 ± 0.57.1 ± 0.44.8 ± 0.15.0 ± 0.1*
Insulin (pmol/l)62.4 ± 7.244.4 ± 7.2§372.6 ± 14329 ± 23
Lactate (mmol/l)0.85 ± 0.070.96 ± 0.170.67 ± 0.050.80 ± 0.04
  • Data are means ± SE. n = 8.

  • *

    * P < 0.05 vs. pretreatment during the clamp.

  • P < 0.05 vs. pretreatment in the basal state,

  • P < 0.01 vs. pretreatment during the clamp,

  • §

    § P < 0.001 vs. pretreatment in the basal state.