TABLE 3

Glucose turnover and indirect calorimetry data during a hyperinsulinemic-euglycemic clamp

	Basal			Clamp
	Pretreatment	10 weeks	Pretreatment	10 weeks
Glucose infusion rate (mg · kg⁻¹ · min⁻¹)	—	—	4.29 ± 0.82	5.05 ± 0.87*
Whole-body glucose disposal (mg · kg⁻¹ · min⁻¹)	2.56 ± 0.16	2.62 ± 0.16	3.91 ± 0.69	4.73 ± 0.70*
Glucose clearance rate (ml · kg⁻¹ · min⁻¹)	1.72 ± 0.13	2.10 ± 0.09†	4.58 ± 0.89	5.29 ± 0.87*
Nonoxidative glucose disposal (mg · kg⁻¹ · min⁻¹)	1.12 ± 0.24	1.16 ± 0.20	1.50 ± 0.50	2.48 ± 0.45*
Endogenous glucose production (mg · kg⁻¹ · min⁻¹)	2.54 ± 0.20	2.66 ± 0.13	−0.49 ± 0.07	−0.20 ± 0.10
Glucose oxidation (mg · kg⁻¹ · min⁻¹)	1.43 ± 0.16	1.46 ± 0.10	2.40 ± 0.22	2.25 ± 0.35
Fat oxidation (mg · kg⁻¹ · min⁻¹)	0.86 ± 0.08	0.84 ± 0.06	0.57 ± 0.06	0.56 ± 0.08
Energy expenditure (kcal · kg⁻¹ · 24 h⁻¹)	22.01 ± 0.48	21.48 ± 0.36	21.36 ± 0.59	21.49 ± 0.68
Glucose (mmol/l)	8.3 ± 0.5	7.1 ± 0.4†	4.8 ± 0.1	5.0 ± 0.1*
Insulin (pmol/l)	62.4 ± 7.2	44.4 ± 7.2§	372.6 ± 14	329 ± 23‡
Lactate (mmol/l)	0.85 ± 0.07	0.96 ± 0.17	0.67 ± 0.05	0.80 ± 0.04‡