TABLE 1

Effect of adrenalectomy in female mice.

Wild type
A-ZIP/F-1
ShamAdrenalectomyShamAdrenalectomy
Body weight, 8 weeks (g)22.9 ± 0.823.4 ± 0.625.7 ± 0.726.9 ± 0.8
Body weight, 10 weeks (g)23.4 ± 0.224.2 ± 0.326.3 ± 0.328.3 ± 0.3*
Blood glucose (mg/dl)149 ± 7128 ± 4*624 ± 35263 ± 9*
Insulin (ng/ml)1.13 ± 0.040.84 ± 0.03*172 ± 1575 ± 11*
Glycated hemoglobin (%)7.4 ± 2.76.6 ± 2.612.8 ± 0.48.9 ± 0.2*
Triglycerides (mg/dl)137 ± 6147 ± 4774 ± 66476 ± 24
Fatty acids (μmol/l)210 ± 8221 ± 19682 ± 24605 ± 15
Corticosterone (ng/ml)113 ± 1234 ± 2*340 ± 5520 ± 5*
Liver weight (g)1.21 ± 0.041.33 ± 0.032.92 ± 0.112.82 ± 0.08
Liver triglycerides (μmol/g tissue)2.43 ± 0.392.96 ± 0.3811.9 ± 3.010.9 ± 2.1
Food intake (g/mouse/day)3.50 ± 0.403.37 ± 0.145.31 ± 0.183.65 ± 0.12*
  • Adrenalectomy was performed at 8 weeks and mice were studied at 10 weeks. Mice were bled in the morning in the nonfasted state. Food intake was measured in individually housed mice 7–11 days after adrenalectomy. Data are means ± SE; n = 6 per group.

  • *

    * P < 0.05 vs. sham group of the same genotype;

  • P < 0.05 vs. wild-type sham.