TABLE 2

Metabolic parameters during basal (12-h fasted) period and hyperinsulinemic-euglycemic clamp in the sham-operated and adrenalectomized wild-type and A-ZIP/F-1 female mice.

Wild type
A-ZIP/F-1
ShamAdrenalectomyShamAdrenalectomy
Body weight (g)21.6 ± 0.622.8 ± 0.821.2 ± 1.122.0 ± 0.6
Basal plasma glucose (mg/dl)137 ± 1376 ± 12*243 ± 1264 ± 18*
Basal plasma insulin (ng/ml)0.96 ± 0.090.47 ± 0.11*1.22 ± 0.270.83 ± 0.16*
Clamp plasma glucose (mg/dl)110 ± 7114 ± 3110 ± 3105 ± 3
Clamp plasma insulin (ng/ml)3.6 ± 0.43.5 ± 0.74.0 ± 0.44.0 ± 1.3
Corticosterone (ng/ml)101 ± 2215 ± 5*251 ± 685 ± 2*
  • Values are means ± SE; n = 6 per group.

  • *

    * P < 0.05 vs. sham group of the same genotype;

  • P < 0.05 vs. wild-type sham.