TABLE 1

Clinical characteristics of nondiabetic subjects from San Giovanni Rotondo according to adiponectin genotypes at positions 45 and 276

SNP 45
SNP 276
T/TT/G + G/GPG/GG/T + T/TP
n260 (65.2)139 (34.8)207 (51.1)198 (48.9)
M/F98/16246/930.4582/12567/1310.37
Age (years)38 ± 1237 ± 110.5538 ± 1138 ± 120.90
% IBW117 ± 21115 ± 180.52117 ± 20115 ± 200.22
Waist (cm)82.7 ± 1280.2 ± 120.1283.0 ± 1280.7 ± 120.14
Systolic blood pressure (mmHg)114 ± 13111 ± 110.02113 ± 12113 ± 120.81
Diastolic blood pressure (mmHg)76 ± 974 ± 80.0976 ± 875 ± 80.15
Fasting blood glucose (mmol/l)5.0 ± 0.54.9 ± 0.50.555.1 ± 0.54.9 ± 0.50.13
Serum insulin (pmol/l)46 ± 2644 ± 210.87*49 ± 2742 ± 220.08*
HOMAIR1.72 ± 1.01.62 ± 0.90.80*1.82 ± 1.11.56 ± 0.90.05*
Cholesterol (mmol/l)5.09 ± 1.094.87 ± 0.910.095.04 ± 1.015.02 ± 1.060.67
HDL cholesterol (mmol/l)1.37 ± 0.341.37 ± 0.300.921.34 ± 0.341.40 ± 0.320.22
Total/HDL ratio3.9 ± 1.23.7 ± 1.10.154.0 ± 1.33.8 ± 1.10.12
Triglycerides (mmol/l)1.06 ± 0.751.09 ± 0.740.81*1.16 ± 0.90.99 ± 0.530.22*
  • Data are means ± SD. Significance tests were based on the comparison of three genotype groups. Because heterozygotes and homozygotes for the minor alleles were virtually identical for every variable, these groups were combined for presentation. Genotypes at positions 45 and 276 were available for 399 and 405 study subjects, respectively.

  • *

    * Significance was tested on log-transformed values.