Frequency of mutations in adiponectin gene

Nondiabetic control subjectsType 2 diabetic subjectsP
n (M/F)452 (312/140)218 (137/81)
I164T*2 (0.4%)7 (3.2%)<0.01
R112C2 (0.4%)1 (0.5%)NS
H241P3 (0.7%)1 (0.5%)NS
R221S1 (0.2%)0 (0.0%)NS
  • Mutation frequencies were compared by Fisher’s exact probability test (for R112C, I164T, R221S, and H241P).

  • *

    * The two nondiabetic control subjects carrying I164T mutation exhibited impaired glucose tolerance by 75-g oral glucose tolerance test.