Frequency of mutations in adiponectin gene
| Nondiabetic control subjects | Type 2 diabetic subjects | P | |
|---|---|---|---|
| n (M/F) | 452 (312/140) | 218 (137/81) | |
| I164T* | 2 (0.4%) | 7 (3.2%) | <0.01 |
| R112C | 2 (0.4%) | 1 (0.5%) | NS |
| H241P | 3 (0.7%) | 1 (0.5%) | NS |
| R221S | 1 (0.2%) | 0 (0.0%) | NS |
Mutation frequencies were compared by Fisher’s exact probability test (for R112C, I164T, R221S, and H241P).
* The two nondiabetic control subjects carrying I164T mutation exhibited impaired glucose tolerance by 75-g oral glucose tolerance test.