TABLE 2

Body weight parameters, blood glucose, plasma insulin in WT and KO mice fed LF or HF diets

WTHFWTLFKOHFKOLFP
GenotypeDiet
n11111110
Body weight (g)28.1 ± 0.9a24.3 ± 0.9b24.4 ± 1.0b22.5 ± 0.9b<0.01<0.005
Weight/length (g/cm)2.85 ± 0.09a2.55 ± 0.07b2.5 ± 0.1b2.39 ± 0.08b<0.01<0.05
Liver weight (g)1.07 ± 0.041.1 ± 0.041.00 ± 0.041.07 ± 0.03NSNS
Total fat weight (g)5.8 ± 2.1a3.4 ± 1.9b3.7 ± 2.1b2.62 ± 1.1b<0.01<0.005
Total fat (%)20.1 ± 0.6a13.5 ± 0.6b14.4 ± 0.6b11.4 ± 0.4b<0.01<0.005
Food intake (kcal)6,045 ± 180a3,505 ± 36b5,652 ± 499a3,713 ± 229bNS<0.01
Fasting glucose (mg/dl)93.64 ± 7.183.64 ± 7.284.91 ± 3.980.8 ± 4.8NSNS
Fasting insulin (ng/ml)0.36 ± 0.03a (n = 8)0.32 ± 0.01 (n = 9)0.28 ± 0.01b (n = 9)0.30 ± 0.01 (n = 8)<0.05NS
  • Data are means ± SE. Fetuin KO and WT mice (females, 10 weeks old) were fed HF or LF diets ad libitum for 9 weeks and were monitored weekly for food intake. End-of-study body weight parameters and total caloric intake are shown. Values were dissimilar superscript letters (a or b) are significantly different from each other based on genotype or diet.