TABLE 6

Paired comparison of sibling pairs discordant for the CALP10 SNP43

VariableAll (n = 80)
Type 2 diabetes (n = 21)
NGT (n = 59)
Sib 1Sib 2Sib 1Sib 2Sib 1Sib 2
Sex (M/F)45/3513/832/27
Age (years)47 ± 1647 ± 1664 ± 1064 ± 1040 ± 1340 ± 12
Age at onset (years)54 ± 752 ± 1654 ± 752 ± 16
BMI (kg/m2)26.5 ± 4.026.2 ± 5.330.0 ± 5.129.2 ± 7.325.3 ± 2.625.2 ± 3.9
WHR0.90 ± 0.080.90 ± 0.090.94 ± 0.090.93 ± 0.100.89 ± 0.080.88 ± 0.08
Fasting plasma glucose (mmol/l)6.7 ± 2.56.5 ± 2.59.9 ± 3.09.2 ± 3.75.5 ± 0.55.5 ± 0.3
Fasting serum insulin (mU/l)11.6 ± 13.48.1 ± 6.5*25.1 ± 21.613.5 ± 10.47.1 ± 3.16.3 ± 3.08
HOMA3.6 ± 5.72.2 ± 2.39.9 ± 8.94.6 ± 3.6§1.5 ± 0.71.4 ± 0.7
  • Data are means ± SD. Sib 1 refers to SNP-43 genotype 11 and 12 carriers and Sib 2 refers to genotype 12 and 22 carriers.

  • *

    * P = 0.013 (for non-insulin-treated: 9.7 ± 9.7 vs. 7.8 ± 5.9 mU/l; P = 0.038);

  • P = 0.040 (for non-insulin-treated: 20.3 ± 17.7 vs. 13.2 ± 10.5; P = 0.18);

  • P = 0.0068 (for non-insulin-treated [n = 67]: 2.7 ± 3.7 vs. 2.0 ± 2.1; P = 0.050);

  • §

    § P = 0.012 (for non-insulin-treated: 7.4 ± 6.6 vs. 4.5 ± 3.7; P = 0.13).