TABLE 2

Metabolic parameters before and after treatment with troglitazone or placebo (all in plasma)

Troglitazone group
Placebo group
BeforeAfterBeforeAfter
Fasting glucose (mmol/l)6.0 ± 0.25.9 ± 0.25.9 ± 0.16.0 ± 0.1
Fasting triglycerides (mmol/l)1.97 ± 0.381.39 ± 0.32*2.05 ± 0.482.36 ± 0.50
Fasting FFA (mmol/l)0.49 ± 0.050.43 ± 0.070.44 ± 0.070.47 ± 0.07
Fasting insulin (pmol/l)64.2 ± 7.646.4 ± 5.9*75.1 ± 10.774.5 ± 7.6
Clamp insulin (pmol/l)392 ± 22376 ± 12437 ± 26425 ± 26
Clamp FFA (mmol/l)0.04 ± 0.010.02 ± 0.01*0.07 ± 0.020.06 ± 0.01
  • Data are means ± SE.

  • *

    * P < 0.05 compared with pretreatment;

  • P < 0.05 compared with placebo treatment.