TABLE 2

Indexes of insulin secretion and insulin sensitivity in subjects with normal glucose tolerance (NGT) and IGT

NGT
IGT
AllFHFH+AllFHFH+
Insulin secretion
    First-phase (pmol/l)711 (651–777)796 (718–883)647 (562–745)*467 (398–548)449 (359–562)480 (378–609)§
    Second-phase (pmol/l)281 (261–304)301 (272–334)266 (239–297)|203 (178–233)209 (176–249)199 (160–248)§
Insulin sensitivity (μmol · kg LBM−1 · min−1 · pmol−1 · l−1)0.236 ± 0.0080.228 ± 0.0110.242 ± 0.0120.202 ± 0.0120.179 ± 0.0190.217 ± 0.016
  • Data for insulin secretion are geometric means (95% CI). Data for insulin sensitivity are means ± SE.

  • *

    * P < 0.01

  • P < 0.001, all IGT vs. all NGT

  • P < 0.0001

  • §

    § P < 0.01, IGT family history (FH)+ vs. NGT FH+.

  • |

    | P < 0.05, NGT FH+ vs. NGT FH;

  • P < 0.02, IGT FH vs. NGT FH.