TABLE 2

Glucose utilization and oxidation in control, FFA-treated, and FFA-plus-metformin–treated islets

Glucose utilization (mmol/l glucose)
Glucose oxidation (mmol/l glucose)
3.316.73.316.7
Control42.5 ± 13.9135.8 ± 47.719.5 ± 8.744.9 ± 13.3*
FFA26.6 ± 11.471.5 ± 22.617.4 ± 11.224.7 ± 7.0
Metformin43.3 ± 10.1127.4 ± 25.418.7 ± 8.837.2 ± 5.0*
FFA + met-formin47.1 ± 14.9130.0 ± 37.718.3 ± 8.632.8 ± 8.7*
  • Data are means ± SD of five separate experiments and are given in picomoles per islet per 120 min. Values of glucose utilization and oxidation at 16.7 mmol/l glucose differed significantly between groups (P = 0.01 and P = 0.02 by ANOVA, respectively)

  • *

    * P < 0.05 vs. control, 3.3 mmol/l glucose

  • P < 0.02 vs. control, 3.3 mmol/l glucose by the Student’s t test

  • P < 0.05 vs. control, 16.7 mmol/l glucose, by the Bonferroni correction.