TABLE 2

Body weight and basal fed plasma glucose and insulin levels in female C57BL/6J mice after treatment with a high-fat or normal diet for 1, 4, and 8 weeks

Start1 week4 weeks8 weeks
Body weight (g)
 High-fat diet18.5 ± 0.1 (42)19.4 ± 0.1 (41)*23.3 ± 0.4 (25)*27.9 ± 0.8 (16)*
 Normal diet18.6 ± 0.1 (40)18.6 ± 0.1 (39)20.7 ± 0.2 (22)21.9 ± 0.3 (14)
Glucose (mmol/l)
 High-fat diet5.7 ± 0.2 (42)7.8 ± 0.2 (23)*6.7 ± 0.3 (17)*9.4 ± 0.6 (10)*
 Normal diet5.5 ± 0.1 (40)5.2 ± 0.2 (25)5.4 ± 0.2 (16)6.3 ± 0.2 (8)
Insulin (pmol/l)
 High-fat diet106 ± 13 (38)71 ± 6 (24)122 ± 19 (18)308 ± 59 (10)*
 Normal diet92 ± 13 (36)87 ± 9 (22)151 ± 13 (16)100 ± 14 (8)
  • Data are means ± SE (n). All analyses were performed as described under research design and methods.

  • *

    * P < 0.05, determined by the Student’s t test.