TABLE 3

AUCinsulin, acute insulin response, and AUCglucose during an IVGTT (1 g glucose/kg intravenously) in C57BL/6J mice after feeding on a high-fat or normal diet for 1, 4, and 8 weeks

IVGTT1 week4 weeks8 weeks
AUCinsulin (nmol/l × 75 min)
 High-fat diet17.2 ± 1.329.4 ± 7.454.4 ± 17.7
 Normal diet17.1 ± 2.437.0 ± 3.930.1 ± 10.2
Acute insulin response (pmol/l)
 High-fat diet518 ± 84328 ± 93755 ± 134
 Normal diet501 ± 72378 ± 109547 ± 98
AUCglucose (mmol/l × 75 min)
 High-fat diet1,013 ± 35*1,193 ± 271,429 ± 19
 Normal diet877 ± 30906 ± 62998 ± 46
  • Data are means ± SE. AUC is the suprabasal area under the curve for insulin and glucose, and acute insulin response is the suprabasal 1- and 5-min insulin response. At all time points, n = 6, except for 1 week (n = 12). Student’s t test

  • *

    * P < 0.05

  • P < 0.001, determined by the Student’s t test.