TABLE 1

Characteristics of carriers of 0, 1, or 2 Lys alleles in codon 23 of KIR6.2 who underwent the OGTT

Glu/GluGlu/LysLys/LysP (ANOVA)P Glu/Glu vs. X/Lys (t test)P Glu/Glu vs. Lys/Lys (t test)
n (M/F)111 (37/74)151 (52/99)36 (10/26)0.751.000.68
IGT/NGT16/9519/1327/290.581.000.44
Age (years)39 ± 138 ± 137 ± 20.490.240.37
BMI (kg/m2)28.0 ± 0.726.8 ± 0.527.0 ± 1.10.370.160.52
WHR0.87 ± 0.010.87 ± 0.010.85 ± 0.010.490.560.24
Fasting plasma glucose (mmol/l)5.1 ± 0.15.1 ± 0.045.1 ± 0.10.790.500.78
Fasting plasma insulin (pmol/l)60 ± 560 ± 454 ± 70.810.830.57
Fasting plasma glucagon (ng/l)63 ± 367 ± 266 ± 40.470.230.57
2-h plasma glucose (mmol/l)5.9 ± 0.16.1 ± 0.16.3 ± 0.30.380.230.23
2-h plasma insulin (pmol/l)354 ± 30362 ± 23357 ± 550.980.850.96
2-h glucagon (ng/l)51 ± 254 ± 255 ± 30.200.080.14
AUCinc glucose (mmol · l−1 · h)*221 ± 14235 ± 12262 ± 250.050.040.02
Insulin sensitivity index*17.7 ± 1.017.2 ± 0.917.4 ± 1.80.140.050.41
  • Data are means ± SE. P values are unadjusted for multiple comparisons.

  • *

    * Adjusted for BMI, age, and WHR.

  • Calculated from the OGTT.