TABLE 2

Characteristics of carriers of 0, 1, or 2 Lys alleles in codon 23 of KIR6.2 who underwent the hyperglycemic clamp

Glu/GluGlu/LysLys/LysP (ANOVA)P Glu/Glu vs. X/Lys (t test)P Glu/Glu vs. Lys/Lys (t test)
n (M/F)31 (12/19)31 (17/14)13 (7/6)0.400.180.36
IGT/NGT7/245/264/90.550.830.57
Age (years)38 ± 339 ± 241 ± 30.770.590.48
BMI (kg/m2)25.1 ± 1.026.1 ± 0.724.8 ± 0.80.570.560.84
WHR0.84 ± 0.010.86 ± 0.010.86 ± 0.020.370.160.33
Fasting plasma glucose (mmol/l)5.1 ± 0.15.0 ± 0.15.1 ± 0.20.680.550.98
Fasting plasma insulin (pmol/l)56 ± 761 ± 1145 ± 70.580.980.32
Fasting plasma glucagon (ng/l)68 ± 368 ± 460 ± 40.330.580.13
AUCinc glucose (mmol · l−1 · h)*196 ± 30298 ± 26297 ± 740.060.020.17
Insulin sensitivity index0.15 ± 0.020.15 ± 0.020.17 ± 0.030.760.510.51
  • Data are means ± SE. P values are unadjusted for multiple comparisons.

  • *

    * Adjusted for BMI and age.

  • Calculated from the hyperglycemic clamp.