TABLE 3

Plasma C-peptide and insulin concentrations during the different phases of the modified hyperglycemic clamp for carriers of 0, 1, or 2 Lys alleles in codon 23 of KIR6.2

Glu/GluGlu/LysLys/LysP (ANOVA)P Glu/Glu vs. X/Lys (t test)P Glu/Glu vs. Lys/Lys (t test)
C-peptide (pmol/l)
 First phase1,311 ± 1141,314 ± 831,295 ± 2151.000.980.94
 Second phase2,463 ± 1352,473 ± 1582,471 ± 3951.000.970.98
 GLP, first phase5,493 ± 3025,885 ± 4315,889 ± 9320.770.470.60
 GLP, second phase8,590 ± 4499,063 ± 8528,473 ± 1,0990.850.740.91
 Maximum10,869 ± 61410,912 ± 1,02910,285 ± 1,2870.910.900.65
Insulin (pmol/l)
 First phase241 ± 41216 ± 23253 ± 730.820.760.89
 Second phase302 ± 49283 ± 37319 ± 1040.910.890.87
 GLP, first phase1,651 ± 2381,752 ± 2221,813 ± 4480.920.700.73
 GLP, second phase3,700 ± 4903,689 ± 5283,452 ± 8730.960.900.79
 Maximum5,512 ± 6265,566 ± 7045,065 ± 1,1370.920.910.71
Glucagon (relative to baseline)
 First phase0.80 ± 0.020.82 ± 0.020.90 ± 0.030.010.060.01
  • Data are means ± SE. P values are unadjusted for multiple comparisons.