TABLE 1.

β-Cell function parameters

Control subjectsType 2 diabetic subjects
Secretion at 5 mmol/l glucose (pmol · min−1 · m−2)136 ± 10279 ± 24*
Slope at 5 mmol/l glucose (pmol · min · −1m−2 mM−1)119 ± 3054 ± 15*
Slope (pmol · min−1 · m−2 · mM−1)148 ± 3853 ± 15
Dynamic control (pd) (pmol · m−2 · mM−1)908 ± 276220 ± 67
Glucose at reference secretion§ (mmol/l)7.2 ± 0.711.7 ± 1.1
Potentiation factor max/min ratio|7.2 ± 1.52.6 ± 0.5
Potentiation factor mean time# (h)5.9 ± 0.2**7.1 ± 0.2
  • *

    * Parameter at 10 mmol/l glucose.

  • Not comparable with control subjects because of the different reference glucose level.

  • P < 0.05, control vs diabetic subjects.

  • §

    § Glucose concentration at which the dose-response function predicts an insulin secretion of 300 pmol · min−1 · m−2.

  • |

    | Ratio between the maximum and minimum values of the potentiation factor.

  • P <0.005, control vs diabetic subjects.

  • #

    # Mean time for the potentiation factor (see research design and methods).

  • **

    ** P < 0.01, control vs. diabetic subjects.