TABLE 2

Indices of insulin secretion and insulin sensitivity in subjects with normal fasting glucose (NFG) and impaired fasting glucose (IFG), subdivided according to oral glucose tolerance test (OGTT), and subjects with type 2 diabetes, according to fasting hyperglycemia (glucose > 7.0 mmol/l).

Fasting glycemiaNFG
IFG
Type 2 diabetes
NFG/NGTNFG/IGTNFG/DGTIFG/NGTIFG/IGTIFG/DGT
n1848610291315
Insulin secretion
    First phase (pmol/l)900 (835–971)724 (630–832)*351 (253–480)†††1,179467 (302–720)‡‡#530 (367–767)§376 (247–572)**
    Second phase (pmol/l)323 (301–346)260 (227–299)*159 (114–223)513221 (139–351)‡‡246 (183–329)§157 (105–235)**
Insulin sensitivity
    ISI (μmol · kg LBM−1 ·     min−1 · pmol−1 · l−1)0.237 ± 0.0080.206 ± 0.0140.164 ± 0.028††0.1040.206 ± 0.0340.117 ± 0.014$§0.161 ± 0.021&**
  • Data for insulin secretion are geometric means (95% CI). Data for insulin sensitivity is mean ± SEM. ANOVA was used with gender, age, BMI, and WHR as covariates. NFG/NGT versus NFG/IGT

  • *

    * P < 0.001; NFG/IGT versus NFG/DGT

  • P = 0.054

  • ††

    †† P = 0.023

  • †††

    ††† P = 0.002; NFG/IGT versus IFG/IGT

  • #

    # P = 0.02; NFG/NGT versus NFG/DGT

  • P < 0.001; NFG/NGT versus type 2

  • **

    ** P < 0.01; NFG/NGT versus IFG/IGT

  • ‡‡

    ‡‡ P < 0.001; IFG/IGT versus type 2

  • &

    & P < 0.05; NFG/NGT versus IFG/DGT

  • §

    § P < 0.002; IFG/IGT versus IFG/DGT

  • $

    $ P = 0.024.