Simulation results for oligogenic models
| 10% prevalence | 1% prevalence | |||||
|---|---|---|---|---|---|---|
| Heritability (%) | 25 | 50 | 25 | 50 | ||
| Number of loci | ||||||
| 4 | 4,112 | 1,815 | 870 | 466 | ||
| 6 | 9,048 | 6,264 | 2,072 | 834 | ||
| 10 | 63,078 | 20,075 | 7,118 | 2,624 | ||
From Rice et al. (24). The table shows number of affected sib-pairs required to detect linkage at a significance level of α = 0.0001 and 80% power for a phenotype with heritability of 25 or 50% and prevalence of 1 or 10% of the general population. These values illustrate values usually contemplated for obesity and type 2 diabetes.