TABLE 1

Simulation results for oligogenic models

10% prevalence
1% prevalence
Heritability (%)25502550
Number of loci
 44,1121,815870466
 69,0486,2642,072834
 1063,07820,0757,1182,624
  • From Rice et al. (24). The table shows number of affected sib-pairs required to detect linkage at a significance level of α = 0.0001 and 80% power for a phenotype with heritability of 25 or 50% and prevalence of 1 or 10% of the general population. These values illustrate values usually contemplated for obesity and type 2 diabetes.