TABLE 1

Insulin release in response to an acute glucose challenge from control islets and islets pre-exposed for 3 days to sera with (CD38+, Ca2+-positive) or without (CD38, Ca2+-negative) anti-CD38 positivity and [Ca2+]i-mobilizing activity

GlucoseInsulin (μU/ml)
3.3 mmol/l16.7 mmol/l
Control42 ± 1895 ± 76
CD38+, Ca2+-positive27 ± 11*45 ± 35*
CD38, Ca2+-negative43 ± 2476 ± 42
  • *

    * P < 0.0001 vs. control and P = 0.0014 vs. negative sera by Bonferroni-Dunn test.