TABLE 2

Insulin release in response to an acute glucose challenge from control islets and islets pre-exposed for 7 days to sera with (CD38+, Ca2+-positive) or without (CD38, Ca2+-negative) anti-CD38 positivity and [Ca2+]i-mobilizing activity

GlucoseInsulin (μU/ml)
3.3 mmol/l16.7 mmol/l
Controls40 ± 1179 ± 39
CD38+, Ca2+-positive28 ± 12*39 ± 17*
CD38, Ca2+-negative35 ± 1562 ± 39
  • *

    * P < 0.0001 vs. control and P = 0.02 vs. negative sera by Bonferroni-Dunn test.