TABLE 1

Metabolic data

Nondiabetic mice
Diabetic mice
ICAM-1+/+ICAM-1−/−ICAM-1+/+ICAM-1−/−
n10101010
Systolic blood pressure (mmHg)96.9 ± 3.9105.0 ± 1.8106.0 ± 2.7100.1 ± 3.9
HbA1c (%)3.7 ± 0.13.7 ± 0.19.4 ± 0.5*9.8 ± 0.2*
Creatinine clearance (μl · min−1 · g body wt−1)6.5 ± 1.35.2 ± 1.625.2 ± 3.9*21.5 ± 2.7*
Body weight (g)29.1 ± 0.731.0 ± 0.717.9 ± 0.8*22.1 ± 1.1*
Kidney weight (g)0.31 ± 0.010.39 ± 0.01*0.47 ± 0.01*0.39 ± 0.02§
Relative kidney weight (mg/g body wt)10.8 ± 0.413.1 ± 0.326.8 ± 1.3*19.3 ± 0.8*
  • Data are means ± SE.

  • *

    * P < 0.0001 vs. nondiabetic ICAM-1+/+ mice;

  • P < 0.05 vs. diabetic ICAM-1+/+ mice;

  • P < 0.0005 vs. nondiabetic ICAM-1+/+ mice;

  • §

    § P < 0.01 vs. diabetic ICAM-1+/+ mice;

  • P < 0.0001 vs. diabetic ICAM-1+/+ mice.