TABLE 2

Follow-up results of subjects with and without a family history of type 2 diabetes

Conventional therapy
Intensive therapy
No family historyFamily historyPNo family historyFamily historyP
n5325452161
BMI (kg/m2)25.1 ± 3.125.4 ± 3.10.5726.4 ± 4.327.8 ± 3.90.002
HbA1c (%)9.2 ± 1.59.3 ± 1.40.467.2 ± 1.07.4 ± 1.30.21
Insulin dose (units · kg−1 · day−1)0.62 ± 0.170.61 ± 0.170.200.66 ± 0.210.73 ± 0.210.03
Triglyceride (mmol/l)0.96 ± 0.58 (0.03)0.98 ± 0.53 (0.18)0.230.86 ± 0.47 (−0.02)*1.04 ± 0.64 (0.01)0.02
Total cholesterol (mmol/l)4.76 ± 0.91 (0.10)4.94 ± 0.93 (0.18)0.034.60 ± 0.78 (−0.01)4.81 ± 0.78 (0.13)<0.05
LDL cholesterol (mmol/l)2.97 ± 0.81 (0.14)3.18 ± 0.82 (0.08)0.022.88 ± 0.69 (−0.007)3.06 ± 0.67 (0.18)§0.02
HDL cholesterol (mmol/l)1.34 ± 0.34 (0.08)1.29 ± 0.36 (0.08)0.291.34 ± 0.34 (−0.02)1.29 ± 0.31 (0.05)0.20
Apolipoprotein B (g/l)0.85 ± 0.220.91 ± 0.240.010.82 ± 0.190.90 ± 0.330.03
Systolic BP (mmHg)116 ± 14116 ± 100.65116 ± 13116 ± 110.62
Diastolic BP (mmHg)75 ± 9.574 ± 8.90.5574 ± 9.374 ± 8.20.75
Natural waist circumference (cm)82.1 ± 9.484.8 ± 10.50.0883.7 ± 10.987.9 ± 12.40.01
Natural WHR0.82 ± 0.080.84 ± 0.070.100.82 ± 0.090.84 ± 0.110.04
  • Data are means ± SD. Data in parentheses represent change from baseline. P represents comparison of no family history versus family history.

  • *

    * P = 0.03;

  • P < 0.001;

  • P = 0.01;

  • §

    § P < 0.01 vs. baseline. BP, blood pressure.