TABLE 3

The five patient groups (lean nondiabetic, lean type 2 diabetic, obese nondiabetic, obese IFG, and obese type 2 diabetic subjects) demonstrating β-cell and islet characteristics

Lean
Obese
Nondiabetic subjectsType 2 diabetic subjectsNondiabetic subjectsIFGType 2 diabetic subjects
Relative β-cell volume/islet (% of islet)52.0 ± 4.138.0 ± 3.9*45.4 ± 2.743.7 ± 3.437.0 ± 2.3†
Islet density (islets/mm2)3.1 ± 0.23.0 ± 0.33.5 ± 0.32.8 ± 0.2‡2.6 ± 0.2†
Mean islet size (μm2)7,140 ± 7956,807 ± 5267,187 ± 5717,131 ± 6957,846 ± 648
Apoptosis/islet (cells/islet)0.07 ± 0.030.47 ± 0.19§0.20 ± 0.7—0.31 ± 0.15
Ki67/islet (cells/islet)0.04 ± 0.020.033 ± 0.010.06 ± 0.02—0.03 ± 0.01

  • Data are means ± SE.

  • *

    * P < 0.01 for lean nondiabetic vs. type 2 diabetic subjects;

  • †

    † P < 0.05 for obese nondiabetic vs. type 2 diabetic subjects;

  • ‡

    ‡ P < 0.05 for obese nondiabetic vs. IFG subjects;

  • §

    § P < 0.05 for lean nondiabetic vs. type 2 diabetic subjects.