The five patient groups (lean nondiabetic, lean type 2 diabetic, obese nondiabetic, obese IFG, and obese type 2 diabetic subjects) demonstrating β-cell and islet characteristics
Lean | Obese | |||||||
---|---|---|---|---|---|---|---|---|
Nondiabetic subjects | Type 2 diabetic subjects | Nondiabetic subjects | IFG | Type 2 diabetic subjects | ||||
Relative β-cell volume/islet (% of islet) | 52.0 ± 4.1 | 38.0 ± 3.9* | 45.4 ± 2.7 | 43.7 ± 3.4 | 37.0 ± 2.3† | |||
Islet density (islets/mm2) | 3.1 ± 0.2 | 3.0 ± 0.3 | 3.5 ± 0.3 | 2.8 ± 0.2‡ | 2.6 ± 0.2† | |||
Mean islet size (μm2) | 7,140 ± 795 | 6,807 ± 526 | 7,187 ± 571 | 7,131 ± 695 | 7,846 ± 648 | |||
Apoptosis/islet (cells/islet) | 0.07 ± 0.03 | 0.47 ± 0.19§ | 0.20 ± 0.7 | — | 0.31 ± 0.15 | |||
Ki67/islet (cells/islet) | 0.04 ± 0.02 | 0.033 ± 0.01 | 0.06 ± 0.02 | — | 0.03 ± 0.01 |
Data are means ± SE.
* P < 0.01 for lean nondiabetic vs. type 2 diabetic subjects;
† P < 0.05 for obese nondiabetic vs. type 2 diabetic subjects;
‡ P < 0.05 for obese nondiabetic vs. IFG subjects;
§ P < 0.05 for lean nondiabetic vs. type 2 diabetic subjects.