TABLE 1

Mean values of GIR (mg · kg−1 · min−1) and FFA (mmol/l) during euglycemic-hyperinsulinemic glucose clamp studies in lean and obese ZDF rats

Age (weeks)ZDF rat groupsGIRFFA (mmol/l)
BasalClamp
6–7Lean20.2 ± 0.80.58 ± 0.060.06 ± 0.01
6–7Obese2.7 ± 0.8*1.07 ± 0.02*0.52 ± 0.04*
22–24Lean14.4 ± 0.50.45 ± 0.030.04 ± 0.01
22–24Obese1.6 ± 0.6*0.64 ± 0.05†0.15 ± 0.03†
22–24Obese+RGZ6.7 ± 0.8+1.05 ± 0.06‡0.26 ± 0.04§

  • Data are means ± SE; n = 5–8;

  • *

    * P < 0.001,

  • †

    † P < 0.05 vs. age-matched lean control;

  • ‡

    ‡ P < 0.001,

  • §

    § P < 0.05 vs. age-matched obese control.