Mean values of GIR (mg · kg−1 · min−1) and FFA (mmol/l) during euglycemic-hyperinsulinemic glucose clamp studies in lean and obese ZDF rats
Age (weeks) | ZDF rat groups | GIR | FFA (mmol/l) | ||
---|---|---|---|---|---|
Basal | Clamp | ||||
6–7 | Lean | 20.2 ± 0.8 | 0.58 ± 0.06 | 0.06 ± 0.01 | |
6–7 | Obese | 2.7 ± 0.8* | 1.07 ± 0.02* | 0.52 ± 0.04* | |
22–24 | Lean | 14.4 ± 0.5 | 0.45 ± 0.03 | 0.04 ± 0.01 | |
22–24 | Obese | 1.6 ± 0.6* | 0.64 ± 0.05† | 0.15 ± 0.03† | |
22–24 | Obese+RGZ | 6.7 ± 0.8+ | 1.05 ± 0.06‡ | 0.26 ± 0.04§ |
Data are means ± SE; n = 5–8;
* P < 0.001,
† P < 0.05 vs. age-matched lean control;
‡ P < 0.001,
§ P < 0.05 vs. age-matched obese control.