TABLE 3

Association of SNPs in the SLC12A3 gene with diabetic nephropathy

GG(Arg/Arg)GA(Arg/Gln)AA(Gln/Gln)GA
SNP47: Exon 23 + 78 G/A (Arg913Gln)
 Nephropathy517 (93.5%)35 (6.3%)1 (0.2%)0.970.03
 Control267 (84.2%)49 (15.5%)1 (0.3%)0.920.08
χ2POdds ratio95% CI
 2 × 319.50.00006
 G vs. A18.50.000022.531.64–3.90
GGGAAAGA
SNP51: intron 24 + 1870 G/A
 Nephropathy475 (92.8%)34 (6.6%)3 (0.6%)0.960.04
 Control266 (84.2%)43 (13.6%)7 (2.2%)0.910.09
χ2POdds ratio95% CI
 2 × 316.10.0003
 G vs. A18.50.000022.441.60–2.3.70
CCCTTTCT
SNP52: intron 25 + 13 C/T
 Nephropathy442 (86.3%)67 (13.1%)3 (0.6%)0.930.07
 Control245 (77.8%)66 (20.9%)4 (1.3%)0.880.12
χ2POdds ratio95% CI
 2 × 310.30.006
 G vs. A10.30.0011.731.23–2.44
CCCTTTCT
SNP58: intron 25 + 2500 C/T
 Nephropathy472 (93.1%)33 (6.7%)1 (0.2%)0.970.03
 Control272 (85.7%)47 (14.0%)1 (0.3%)0.920.08
χ2POdds ratio95% CI
 2 × 315.10.0005
 G vs. A14.30.00012.311.48–3.61
  • Cases are expressed as numbers of subjects. Percentages of the totals are shown in parentheses.