Association of IRS1 variants with type 2 diabetes in Pima Indians
| Homozygote-common allele | Heterozygote | Homozygote minor allele | Odds ratio (95% CI) | P | |
|---|---|---|---|---|---|
| −7120G/A | |||||
| Genotype | G/G | G/A | A/A | ||
| Diabetic | 326 (61) | 182 (34) | 30 (6) | ||
| Nondiabetic | 210 (66) | 96 (31) | 10 (3) | 0.70 (0.54–0.91) | 0.01 |
| −2223C/T | |||||
| Genotype | C/C | C/T | T/T | ||
| Diabetic | 413 (77) | 119 (22) | 7 (1) | ||
| Nondiabetic | 255 (79) | 63 (20) | 4 (1) | 0.81 (0.56–1.17) | 0.26 |
| −446G/A | |||||
| Genotype | G/G | G/A | A/A | ||
| Diabetic | 363 (65) | 182 (33) | 14 (2) | ||
| Nondiabetic | 237 (72) | 84 (26) | 6 (2) | 0.66 (0.48–0.90) | 0.01 |
| Ala804 (GCG/GCA) | |||||
| Genotype | G/G | G/A | A/A | ||
| Diabetic | 201 (34) | 299 (51) | 86 (15) | ||
| Nondiabetic | 91 (27) | 193 (56) | 59 (17) | 1.29 (1.02–1.63) | 0.04 |
Data are n (%). The odds ratio is given for a one-allele difference in the number of common alleles, adjusted for age and sex, and calculated by binomial generalized estimating equations that account for family membership; the P value is that for the null hypothesis of no difference in allele frequency between diabetic and nondiabetic individuals calculated by the Cochran-Armitage test for a linear trend in proportions.