TABLE 1

Association of IRS1 variants with type 2 diabetes in Pima Indians

Homozygote-common alleleHeterozygoteHomozygote minor alleleOdds ratio (95% CI)P
−7120G/A
 GenotypeG/GG/AA/A
 Diabetic326 (61)182 (34)30 (6)
 Nondiabetic210 (66)96 (31)10 (3)0.70 (0.54–0.91)0.01
−2223C/T
 GenotypeC/CC/TT/T
 Diabetic413 (77)119 (22)7 (1)
 Nondiabetic255 (79)63 (20)4 (1)0.81 (0.56–1.17)0.26
−446G/A
 GenotypeG/GG/AA/A
 Diabetic363 (65)182 (33)14 (2)
 Nondiabetic237 (72)84 (26)6 (2)0.66 (0.48–0.90)0.01
Ala804 (GCG/GCA)
 GenotypeG/GG/AA/A
 Diabetic201 (34)299 (51)86 (15)
 Nondiabetic91 (27)193 (56)59 (17)1.29 (1.02–1.63)0.04
  • Data are n (%). The odds ratio is given for a one-allele difference in the number of common alleles, adjusted for age and sex, and calculated by binomial generalized estimating equations that account for family membership; the P value is that for the null hypothesis of no difference in allele frequency between diabetic and nondiabetic individuals calculated by the Cochran-Armitage test for a linear trend in proportions.