TABLE 1

Incremental areas under the plasma glucose, insulin, and C-peptide curves as well as the total amount of insulin secreted (total ISR) during GLP-1 and saline infusion

InfusionSalineGLP-1 (0.5 pmol · kg−1 · min−1)GLP-1 (1.0 pmol · kg−1 · min−1)GLP-1 (2.0 pmol · kg−1 · min−1)
Type 2 diabetic subjects
 AUC glucose (mmol/l/150 min)1,882.0 ± 12.41,805.3 ± 10.61,567.9 ± 9.41,306.0 ± 5.5
 AUC insulin (nmol/l/150 min)8.3 ± 0.414.2 ± 3.332.4 ± 8.263.0 ± 37.5
 AUC C-peptide (nmol/150 min)128.7 ± 19.2164.7 ± 24.5323.7 ± 120.4369.9 ± 120.4
 Total ISR (pmol · kg−1 · min−1)332.2 ± 50.5629.5 ± 52.6910.1 ± 107.4974.6 ± 197.6
Control subjects
 AUC glucose (mmol/l/150 min)1,596.1 ± 9.11,297.8 ± 4.81,093.9 ± 4.3972.1 ± 2.4
 AUC insulin (nmol/l/150 min)37.8 ± 10.281.2 ± 23.6104.2 ± 26.7159.7 ± 43.6
 AUC C-peptide (nmol/l/150 min)238.9 ± 49.8380.5 ± 88.9408.0 ± 97.2587.4 ± 127.6
 Total ISR (pmol · kg−1 · min−1)710.9 ± 123.21,201.2 ± 179.41411.7 ± 222.42414.6 ± 242.5
  • Data are means ± SE.