TABLE 1

Characteristics of nondiabetic (db/+) and diabetic (db/db) female mice, according to age

6 weeks
10–12 weeks
16–18 weeks
db/+db/dbdb/+db/dbdb/+db/db
Body weight (g)17.6 ± 0.6 (8)24.2 ± 0.5 (8)*21.6 ± 0.3 (5)42.3 ± 1.2 (9)*26.3 ± 5.3 (4)44.2 ± 1.1 (8)*
Heart dry weight (mg)18.9 ± 0.6 (8)18.5 ± 0.4 (8)23.5 ± 0.6 (5)24.5 ± 0.6 (9)25.5 ± 1.1 (4)26.7 ± 0.7 (8)
Plasma glucose (mmol/l)13.2 ± 0.6 (8)14.2 ± 1.0 (8)14.1 ± 0.7 (5)37.8 ± 3.0 (9)*15.3 ± 1.5 (4)45.0 ± 2.5 (8)*
Plasma insulin (μU/ml)21 ± 8 (3)85 ± 27 (5)*9 ± 1 (3)297 ± 51 (7)*7 ± 2 (3)257 ± 40 (9)*
Plasma FFA (mmol/l)0.9 ± 0.2 (4)1.9 ± 0.2 (3)*1.2 ± 0.4 (4)2.3 ± 0.3 (7)*1.0 ± 0.2 (4)2.4 ± 0.4 (7)*
  • Values are mean ± SE. Numbers in parentheses indicate the number of animals in each group.

  • *

    * P < 0.05 compared with db/+ mice at the same age. FFA, free fatty acids