All-cause and cardiovascular death and incidence of myocardial infarction and stroke in relation to diabetes and ISPs
| No diabetes | Diabetes | |||||
|---|---|---|---|---|---|---|
| Zero to one ISP in top quartile | Two to five ISPs in top quartile | Zero to one ISP in top quartile | Two to five ISPs in top quartile | |||
| n | 3,808 | 1,921 | 186 | 135 | ||
| All-cause mortality (n) | 416 | 410 | 38 | 46 | ||
| Age-adjusted RR | reference | 2.1 (1.8–2.4) | 2.1 (1.5–2.9) | 3.8 (2.8–5.1) | ||
| Risk factor adjusted* | reference | 1.6 (1.4–1.8) | 1.8 (1.3–2.6) | 2.5 (1.8–3.5) | ||
| Age-adjusted RR | reference | 1.8 (1.2–2.8) | ||||
| Risk factor adjusted* | reference | 1.5 (0.93–2.4) | ||||
| CVD mortality (n) | 159 | 174 | 16 | 23 | ||
| Age-adjusted RR | reference | 2.3 (1.9–2.9) | 2.3 (1.4–3.9) | 4.9 (3.2–7.6) | ||
| Risk factor adjusted* | reference | 1.7 (1.4–2.2) | 1.8 (1.1–3.0) | 2.8 (1.8–4.5) | ||
| Age-adjusted RR | reference | 2.2 (1.1–4.1) | ||||
| Risk factor adjusted† | reference | 2.2 (1.2–4.2) | ||||
| Cardiac events (n) | 277 | 280 | 21 | 30 | ||
| Age-adjusted RR | reference | 2.2 (1.8–2.6) | 1.7 (1.1–2.7) | 3.7 (2.6–5.4) | ||
| Risk factor adjusted* | reference | 1.6 (1.3–1.9) | 1.3 (0.83–2.1) | 2.2 (1.5–3.2) | ||
| Age-adjusted RR | reference | 2.2 (1.2–3.8) | ||||
| Risk factor adjusted† | reference | 2.2 (1.2–3.8) | ||||
| Stroke (n) | 122 | 94 | 8 | 13 | ||
| Age-adjusted RR | reference | 1.7 (1.3–2.2) | 1.5 (0.8–3.2) | 3.9 (2.2–6.9) | ||
| Risk factor adjusted* | reference | 1.4 (1.1–1.9) | 1.2 (0.6–2.5) | 2.5 (1.4–4.6) | ||
| Age-adjusted RR† | reference | 2.4 (0.98–5.8) | ||||
| Ischemic stroke (n) | 100 | 80 | 8 | 11 | ||
| Age-adjusted RR | reference | 1.7 (1.3–2.3) | 1.9 (0.91–3.8) | 4.0 (2.1–7.4) | ||
| Risk factor adjusted* | reference | 1.4 (1.0–1.9) | 1.5 (0.7–3.1) | 2.5 (1.3–4.8) | ||
| Age-adjusted RR | reference | 2.0 (0.80–5.0) | ||||
* RR adjusted for age, BMI, smoking, tobacco consumption, cholesterol, triglycerides, physical inactivity, systolic blood pressure, and medication for hypertension.
† Number of covariables were reduced in a backward stepwise Cox regression due to the small number of events. Age, cholesterol, and ISP levels remained in the final models for cardiovascular death and cardiac events. Age and ISP levels remained in the final model for stroke.