TABLE 3

All-cause and cardiovascular death and incidence of myocardial infarction and stroke in relation to diabetes and ISPs

No diabetes
Diabetes
Zero to one ISP in top quartileTwo to five ISPs in top quartileZero to one ISP in top quartileTwo to five ISPs in top quartile
n3,8081,921186135
All-cause mortality (n)4164103846
 Age-adjusted RRreference2.1 (1.8–2.4)2.1 (1.5–2.9)3.8 (2.8–5.1)
 Risk factor adjusted*reference1.6 (1.4–1.8)1.8 (1.3–2.6)2.5 (1.8–3.5)
 Age-adjusted RRreference1.8 (1.2–2.8)
 Risk factor adjusted*reference1.5 (0.93–2.4)
CVD mortality (n)1591741623
 Age-adjusted RRreference2.3 (1.9–2.9)2.3 (1.4–3.9)4.9 (3.2–7.6)
 Risk factor adjusted*reference1.7 (1.4–2.2)1.8 (1.1–3.0)2.8 (1.8–4.5)
 Age-adjusted RRreference2.2 (1.1–4.1)
 Risk factor adjustedreference2.2 (1.2–4.2)
Cardiac events (n)2772802130
 Age-adjusted RRreference2.2 (1.8–2.6)1.7 (1.1–2.7)3.7 (2.6–5.4)
 Risk factor adjusted*reference1.6 (1.3–1.9)1.3 (0.83–2.1)2.2 (1.5–3.2)
 Age-adjusted RRreference2.2 (1.2–3.8)
 Risk factor adjustedreference2.2 (1.2–3.8)
Stroke (n)12294813
 Age-adjusted RRreference1.7 (1.3–2.2)1.5 (0.8–3.2)3.9 (2.2–6.9)
 Risk factor adjusted*reference1.4 (1.1–1.9)1.2 (0.6–2.5)2.5 (1.4–4.6)
 Age-adjusted RRreference2.4 (0.98–5.8)
Ischemic stroke (n)10080811
 Age-adjusted RRreference1.7 (1.3–2.3)1.9 (0.91–3.8)4.0 (2.1–7.4)
 Risk factor adjusted*reference1.4 (1.0–1.9)1.5 (0.7–3.1)2.5 (1.3–4.8)
 Age-adjusted RRreference2.0 (0.80–5.0)
  • *

    * RR adjusted for age, BMI, smoking, tobacco consumption, cholesterol, triglycerides, physical inactivity, systolic blood pressure, and medication for hypertension.

  • Number of covariables were reduced in a backward stepwise Cox regression due to the small number of events. Age, cholesterol, and ISP levels remained in the final models for cardiovascular death and cardiac events. Age and ISP levels remained in the final model for stroke.