TABLE 2

Univariate Spearman correlation coefficients between simple measures of insulin resistance and directly measured insulin sensitivity obtained from the FSIGT among nondiabetic subjects in the IRAS

Simple measure (abbreviation) [reference]FormulaSpearman r with SI from FSIGT
All subjectsHANHWAA
n981342392247
Fasting only
 Fasting insulin (I0) (FI) [5]I0−0.68−0.72−0.62−0.59
 BMI (BMI)weight (kg)/height (m)2−0.54−0.62−0.52−0.39
 ISI (ISI) [9]10,000/(I2 × G2)0.680.720.630.59
 HOMA IR (HOMA-IR) [7](I0 × G0)/22.5−0.68−0.72−0.63−0.59
 FIRI (FIRI) [8](I0 × G0)/25−0.68−0.72−0.63−0.59
 Insulin/glucose (IGR) [13]I0/G0−0.65−0.71−0.59−0.57
 McAuley index (McAuley) [18]e[2.63 − 0.28 ln(I0 − 0.31 ln(Tg0)]0.670.720.610.58
 Raynaud (Raynaud) [10]40/I00.680.720.620.59
 QUICKI (QUICKI) [11]1/[log I0 + log G0]0.680.710.630.59
 Bennett’s SI (BFSI) [13]1/(log I0 × log G0)0.680.720.620.59
 Belfiore (basal) (ISIgly_b) [15]2/[(I0/N × G0/N) + 1]0.680.720.630.59
Fasting and/or 2 h
 2-h insulin/2-h glucose (IGR2h) [13]I2/G2−0.59−0.60−0.55−0.52
 2-h ISI (ISI2h) [9]10,000/(I2 × G2)0.690.680.680.66
 Stumvoll (Stum_nodem) [20]0.156 − 0.0000459 × I2 − 0.0000321 × I0 − 0.00541 × G00.710.700.710.67
 Stumvoll-demographic (Stum_wdem) [20]0.222 − 0.00333 × BMI − 0.0000779 × I2 − 0.000422 × age0.740.750.720.69
 Gutt ISI0, 120* (ISI0, 120) [19](m/MPG) / log MSI0.680.670.690.64
 Avignon’s SiM (SiM) [17][(w × Sib) + Si2h] / 20.770.790.750.70
 Belfiore (area) (ISIgly_a) [15]2/[(Ia/mIa + Ga/mGa) + 1]0.730.720.720.66
  • *

    * m = (75,000 mg + (fasting glucose − 2-h glucose) × 0.19 × body wt) / 120 min; MPG = mean of fasting and 2-h glucose concentrations (mg/dl); MSI = mean of fasting and 2-h insulin concentrations (mU/l).

  • w = mean Si2h / mean Sib, Sib = 108 / (fasting insulin (μU/ml) × fasting glucose (mg/dl) × VD), Si2h = 108 / (2-h insulin (μU/ml) × 2-h glucose (mg/dl) × VD), where VD = 150 ml/kg body wt. AA, African American; G0, fasting glucose; G2, 2-h glucose; Ga, glucose area; HA, Hispanic American; Ia, insulin area; I0, fasting insulin; I2, 2-h insulin; Ia, insulin area; mG0, mean fasting glucose; mGa, mean glucose area; mI0, mean fasting insulin; mIa, mean insulin area; NHW, non-Hispanic white.