TABLE 1

Parameters derived from the analysis of the hyperglycemic clamp (HGC) and the OGTT

ParameterDefinitionUnits
First-phase concentrationArea above basal under the curve of insulin concentration between 0 and 10 min of the HGCpmol/l per 10 min
Second-phase concentrationAverage insulin concentration during the last 40 min of the HGCpmol/l
ISInsulin sensitivity during the HGCμmol · min−1 · m−2 BSA per pmol/l
First-phase secretionAmount of C-peptide secreted by the β-cell during the first-phase secretion of the HGCpmol · m−2 BSA
Second-phase secretionAmount of C-peptide secreted by the β-cell during the second-phase secretion of the HGCpmol per 120 min (or 180 min) m−2 BSA
βSensitivity of β-cell second-phase secretion to glucose during the HGC(pmol · min−1 · m−2 BSA) per mmol
δApparent delay (time constant) of β-cell second-phase secretion during the HGCmin
OGTT β-index (log units)β-cell function during the OGTTlog(pmol · min−2 · m−2 BSA)