TABLE 3

Change from baseline in neurophysiological and sensory variables after 6 and 12 weeks of C-peptide and placebo

C-peptide (n = 26)
Placebo (n = 20)
6 weeks12 weeks6 weeks12 weeks
MCV (m/s)0.8 ± 0.32*0.1 ± 0.290.3 ± 0.41−0.7 ± 0.39
CMAP (mV)0.4 ± 0.36−0.1 ± 0.290.4 ± 0.270.2 ± 0.29
SCV (m/s)1.6 ± 0.76*2.7 ± 0.850.6 ± 0.910.6 ± 0.80
SNAP (μV)0.6 ± 1.100.7 ± 1.190.9 ± 0.953.4 ± 0.98
Cold threshold (AU)0.3 ± 0.460.2 ± 0.20
Heat threshold (AU)0.3 ± 0.310.1 ± 0.26
Vibration threshold (AU)−0.2 ± 0.070 ± 0.06
  • Data are means ± SE. Improvements in nerve function are indicated by positive differences for MCV, CMAP, SCV, and SNAP and negative differences for cold, heat, and vibration perception thresholds. AU, arbitrary units.

  • *

    * P < 0.05 and

  • P < 0.01 for change from baseline.

  • P < 0.05 for change greater than in the placebo group.