TABLE 2

Association studies of the KCNJ11 E23K variants in all cohorts

Genotype/allelesCase subjects
Case totalControl subjects
Control total
W2SYT2DEFSECACC
n6222328548553271182
E23K
E/E219 (0.35)89 (0.38)308 (0.36)358 (0.42)133 (0.41)491 (0.42)
E/K303 (0.49)109 (0.47)412 (0.48)382 (0.45)152 (0.46)534 (0.45)
K/K100 (0.16)34 (0.15)134 (0.16)115 (0.13)42 (0.13)157 (0.13)
P0.03
E741 (0.60)287 (0.62)1228 (0.60)1098 (0.64)418 (0.64)1516 (0.64)
K503 (0.40)177 (0.38)680 (0.40)612 (0.36)236 (0.36)848 (0.36)
OR (95% CI)1.18 (1.04–1.34)
P (two tailed)0.01
  • Values in parenthesis represent genotype or allelic genotype frequency. Genotype distributions in type 2 diabetic subjects and population control subjects are shown for each individual cohort. W2S, Warren 2 sib-pair probands; YT2D, young-onset type 2 diabetes.