TABLE 3

Association studies of the ABCC8 exon16 and exon18 variants in all cohorts

Genotype/allelesCase subjects
Case totalControl subjects
Control total
W2SYT2DEFSECACC
n6222328548553271182
Exon 18
 C/C558 (0.90)209 (0.90)767 (0.90)772 (0.90)285 (0.87)1057 (0.89)
 C/T64 (0.10)22 (0.10)86 (0.10)79 (0.09)41 (0.12)120 (0.10)
 T/T0 (0.00)1 (0.00)1 (0.00)4 (0.01)1 (0.00)5 (0.01)
P*0.77
 C1180 (0.95)440 (0.95)1620 (0.95)1623 (0.95)611 (0.93)2234 (0.95)
 T64 (0.05)24 (0.05)88 (0.05)87 (0.05)43 (0.07)130 (0.05)
  OR (95% CI)0.93 (0.71–1.23)
  P (two tailed)0.63
Exon 16
 −3c/c202 (0.33)64 (0.28)266 (0.31)301 (0.35)103 (0.32)404 (0.34)
 −3c/t306 (0.49)138 (0.60)444 (0.52)397 (0.46)167 (0.51)564 (0.48)
 −3t/t114 (0.18)30 (0.13)144 (0.17)157 (0.18)57 (0.18)214 (0.18)
P0.161
 −3t710 (0.57)266 (0.57)976 (0.57)999 (0.58)373 (0.57)1372 (0.58)
 −3c534 (0.43)198 (0.43)732 (0.43)711 (0.42)281 (0.43)992 (0.42)
  OR (95% CI)1.04 (0.91–1.18)
  P (two tailed)0.57
  • Values in parentheses represent genotype or allelic genotype frequency. Genotype distributions in type 2 diabetic subjects and population control subjects are shown for each individual cohort.

  • *

    * For exon 18 CT + TT versus CC. W2S, Warren 2 sib-pair probands; YT2D, young-onset type 2 diabetes.