TABLE 4

Magnitude of linkage disequilibrium (D′ and r2) across the ABCC8/KCNJ11 locus calculated from the rare allele at each locus in 436 nondiabetic families

HaplotypeD′r2P
KCNJ11 E23K (K)/ABCC8 ex 16 (−3c)−0.0170.00530.025
KCNJ11 E23K (K)/ABCC8 ex18 (T)−0.1140.000380.88
ABCC8 ex 16 (−3c)/ABCC8 ex18 (T)0.9060.031<0.001