TABLE 1

Clinical and biochemical characteristics of 519 unrelated glucose-tolerant whites classified according to E23K Kir6.2 genotype

E/EE/KK/KP (KK vs. EX)P (EE vs. XK)
n (men/women)198 (93/105)246 (111/135)75 (38/37)
Age (years)57 ± 1056 ± 1058 ± 10
BMI (kg/m2)25.3 ± 3.226.1 ± 3.826.4 ± 4.60.240.013
Waist (cm)85.9 ± 10.886.4 ± 12.088.6 ± 11.00.510.22
Waist-to-hip ratio0.89 ± 0.110.87 ± 0.100.89 ± 0.090.910.006
Fasting plasma glucose (mmol/l)5.0 ± 0.45.1 ± 0.45.1 ± 0.50.670.16
Fasting serum insulin (pmol/l)39 ± 1939 ± 1740 ± 270.400.26
Insulinogenic index31.0 ± 22.127.6 ± 14.627.6 ± 16.30.350.022
AUC 0–120 min for serum insulin24,164 ± 14,75622,033 ± 12,27122,379 ± 11,5150.570.014
  • Data are means ± SD.