TABLE 2

IC50 (in μmol/l) calculated from in vitro kinase assays Embedded Image

A-304000A-291007
p384.860.64
JNK>503.47
Casein kinase 2>50>50
AKT 1>50>50
PKA>507.3
PKC γ>50>50
MAPKAP 2>50>50
AMP kinase>50>50
c-Met>50>50
IGF receptor>50>50
Polo-like kinase>50>50
LCK kinase>50>50