TABLE 1

Genes differentially expressed in adipose tissue in diabetic BTBR-ob/ob mice

AccessionDescriptionFoldP
Downregulated in BTBR-ob/ob
 Adipocyte differentiation
  X04673Adipsin (Complement D)−2.2<0.0001
  AF053943Adipocyte-enhancer binding protein−2.5<0.0001
 Signal transduction
  X76290Sonic hedgehog homolog−2.4<0.0001
  M60596GABA-A receptor delta-subunit gene−2.0<0.0001
  AF047716Kinase anchor protein 7 (Akap 18)−2.0<0.0001
  AB016080Kinase interacting protein 2 (Kip2)−1.9<0.0001
  AW046879ACP33 (acidic cluster protein 33)−1.8<0.0029
  M31312Fc receptor, IgG, low affinity IIb−1.7<0.0001
  AF036585Semaphorin 6B−1.8<0.0001
  U67188Regulator of G-protein signaling 5−1.50.0363
  U60473CD59a antigen−2.0<0.0001
  AA960657Interferon activated gene 203−1.50.0187
  X99347Lipopolysaccharide binding protein−1.6<0.0001
 Metabolism
  Z22216Apolipoprotein CII−1.50.0354
  AB003305Proteasome subunit, beta type 5−1.6<0.0001
  L42115Adipocyte amino acid transporter−4.4<0.0001
 Others
  X05862H2B histone gene−3.0<0.0001
  D88792Cysteine-rich protein 2−1.7<0.0001
  AV013428Crystallin, alpha 2−1.7<0.0001
  U72032Eosinophil-associated ribonuclease 1−1.60.0107
  AB031291Neuronal protein NP25−1.60.0002
  L23971Fragile X mental retardation syndrome 1−1.7<0.0001
  AW124972DNA segment, ERATO Doi 21, expressed−1.60.0014
  AF017994Peg1/MEST protein−1.7<0.0001
  C78850Envelope protein (env) gene−1.6<0.0001
Upregulated in BTBR-ob/ob
 Inflammatory
  M75721Serine protease inhibitor 1-11.9<0.0001
  M25529Serine protease inhibitor 1-24.1<0.0001
  M75720Serine protease inhibitor 1-31.7<0.0001
  M75718Serine protease inhibitor 1-42.1<0.0001
  M75717Serine protease inhibitor 1-52.0<0.0001
  X00945Serine protease inhibitor 1-63.2<0.0001
  X70296Serine proteinase inhibitor, clade E1.50.0267
  AF030636Cytokine subfamily B 133.3<0.0001
  M31418Interferon activated gene 202A2.5<0.0001
  AJ007971Interferon-inducible GTPase2.6<0.0001
  AF035684Small inducible cytokine A21a (leucine)1.8<0.0001
  X70058Small inducible cytokine A71.60.0002
  AB001607Prostaglandin 12 synthase1.7<0.0001
  D10204Prostaglandin E receptor 31.50.0293
 Metabolism
  AJ001418Pyruvate dehydrogenase kinase 41.9<0.0001
  AF009605Phosphoenolpyruvate carboxykinase 11.50.0018
  M74570Alcohol dehydrogenase family 11.50.0107
  AA144642Fructose 1,6-bisphosphate aldolase1.60.0001
  X61172Mannosidase 2, alpha 11.6<0.0001
  Y12887Carboxylesterase 12.5<0.0001
  AW226939Esterase 11.7<0.0001
  L16992Ketoacid dehydrogenase E11.6<0.0001
  L07645Histidine ammonia lyase2.7<0.0001
  U51805Arginase 12.0<0.0001
  Y08027ART31.50.0042
  M55544Guanylate nucleotide binding protein 11.9<0.0001
 Signal transduction
  AF024621γ-aminobutyric acid receptor1.8<0.0001
  AF071180Formyl peptide receptor, related 22.2<0.0001
  AJ010045Guanine nucleotide regulatory protein1.6<0.0001
  X60367Retinol binding protein 1, cellular1.50.0265
 Others
  M27134Histocompatibility 2, K region locus 22.4<0.0001
  AJ243851LIM homeobox protein 91.70.0019
  X83601Pentaxin related gene1.60.0001
  X83569Neuronatin1.7<0.0001
  AF038939Paternally expressed gene 31.6<0.0001
  M16238Fibrinogen-like protein 21.50.0021
  AA647799Osteoglycin1.50.0228
  L12367Adenylyl cyclase-associated CAP protein1.50.0442
  X65128Growth arrest specific 11.50.0026
  AB020886Src Suppressed C Kinase Substrate1.50.0013
  M91380Follistatin-like1.50.0040
  M96827Haptoglobin1.7<0.0001